WS9761 A and B: new non-steroidal androgen-receptor antagonists produced by a Streptomyces.
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Napyradiomycins A and B1: non-steroidal estrogen-receptor antagonists produced by a Streptomyces.
Estrogen-receptor antagonists are used in the therapy of estrogen-responsive diseases including breast cancer and endometrial cancer. Tamoxifen, the non-steroidal estrogen-receptor antagonist, is now the first choice of anti-hormonal treatment for advanced breast cancer. In spite of its effectiveness, the long-term use of tamoxifen frequently results in tumor resistance to itself and its relate...
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Dehydroepiandrosterone (DHEA), the most abundant steroid in human circulating blood, is metabolized to sex hormones and other C19-steroids. Our previous collaborative study demonstrated that androst-5-ene-3beta,17beta-diol (Adiol) and androst-4-ene-3,17-dione (Adione), metabolites of DHEA, can activate androgen receptor (AR) target genes. Adiol is maintained at a high concentration in prostate ...
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Asukamycin, a new antibiotic, has been isolated from the culture broth of a streptomycete designated as Streptomyces nodosus subsp. asukaensis. The antibiotic inhibits the growth of Gram-positive bacteria including Nocardia asteroides. The empirical formula of antibiotic asukamycin has been proposed as C29H22N2O9 (M.W. 542). An acute toxicity of the antibiotic in mice is LD50 48.5 mg/kg by intr...
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Two new antibiotics have been obtained from culture filtrates of an unidentified species of Streptomyces. These antibiotics are of special interest because of their high potency and their extreme toxicity. Because they are yellow in color and are produced by a Streptomyces, they have been named xanthomycin A and xanthomycin B. The organism, designated Streptomyces 94, is one of a series isolate...
متن کاملKobutimycins A and B, new alkaloid antibiotics produced by a Streptomyces strain.
Newalkaloid antibiotics named kobutimycins A (1) and B (2) (Fig. 1) were isolated from the culture broth of a streptomycete strain No. TA3341, which was isolated from a soil sample collected at Kobutizawa, Yamanashi Prefecture, Japan. The strain has been classified as Streptomyces sp. TA3341. In this communication we wish to report the fermentation, isolation, structural elucidation and biologi...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1993
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.46.1901